Partnering
Opportunities to collaborate
Makoto seeks to collaborate with research-based pharmaceutical companies on projects of mutual interest. These collaborations focus on the discovery of new chemical entities as well as target elucidation of known active compounds in various stages of pre-clinical and clinical development.
Insights generated
The insights which Makoto generates enable its pharmaceutical partners to identify
- Pathways activated by partners’ small molecules
- Mechanism of action of compounds and their targets
- Novel targets and mechanisms of active small molecules
- Off-targets of small molecules
Benefits
- Identify on-target versus off-target effects of active small molecules
- Identify the origin of various potential toxicities of active compounds
- Make more informed compound development and prioritization decisions earlier
- Rescue stranded pharmaceutical assets that have unknown mechanisms of action
- Reposition compounds with good clinical safety profiles but poor efficacy in alternate disease areas
- Enable rational optimization of active compounds